SOCIETY FOR IMAGE-GUIDED NEUROINTERVENTIONS (SIGN) AND
CHILDREN'S BRAIN TUMOR DRUG DELIVERY CONSORTIUM (CBTDDC)
Johns Hopkins at Mt. Washington Conference Center, Pullen Plaza room
DAY 1. June 10, 2019 Baltimore, MD
7:30 - 8:00 Registration and continental breakfast
Mini Symposium 1 Advances in Device Navigation
Chair: Paul Bottomley (Johns Hopkins University, Baltimore, MD, USA)
Chengyan Chu (Johns Hopkins University, Baltimore, MD, USA)
Various devices have been developed to assist in image guided neurointervention. This minisymposium will cover strategies that are exploited to improve precision and safety of navigating devices towards selected target in the brain, including parenchymal needle placement or guiding endovascular catheters.
8:00 - 8:15 Invited: Zhengchu Tan, Imperial College London, UK
EDEN2020: A Bio-Inspired Robotic Platform for Neurosurgery
8:15 - 8:30 Invited: Iulian Iordachita, Johns Hopkins University, Baltimore, MD, USA
Shape Sensing Based Navigation of Flexible Medical Devices
8:30 - 8:45 Invited: Steve Hetts, University of California at San Francisco, CA, USA
Endovascular Interventional MRI: Catheter Development and Navigation
8:45 - 9:00 Invited: Parag Karmarkar, Johns Hopkins University, Baltimore, MD, USA
Endovascular Devices for MRI Guided Interventions,
9:00 - 9:15 Coffee break and discussion
Mini Symposium 2 Artificial Intelligence and Virtual Reality
Chair: Piotr Dziedzic (Johns Hopkins University, Baltimore, MD, USA)
Rohit Srivastava (Johns Hopkins University, Baltimore, MD, USA)
Recently there has been an explosion of machine learning applications in biomedicine. Imaging sciences seem to particularly benefit from this development and the application of these technologies is still in its infancy. This minisymposium will focus on the latest advances as applied to imaging drug delivery to the brain.
9:15 - 9:30 Invited: Brian Kim, Johns Hopkins University, Baltimore, MD, USA
Eye Surgery Automation Through Visual Servoing Based on Machine Learning by Demonstration
9:30 - 9:45 Invited: Ciprian Ionita, University of Buffalo, NY, USA
Machine Learning to Guide Endovascular Treatment
9:45 - 10:00 Invited: Meiyappan Solaiyappan, Johns Hopkins University, Baltimore, MD, USA
Stereoscopic 3D - A Game-Changer in High Precision Visualization
10:00 - 10:15 Coffee break and discussion
Opening Ceremony
10:15 - 10:30 President of SIGN - Miroslaw Janowski, Johns Hopkins University, Baltimore, MD, USA
Chairman of CBTDDC - David Walker, University of Nottingham, UK
10:30 - 11:00 Keynote address: Prof. David Walker
Why Re-Engineer Drug Delivery to CNS Tumours?
David Walker is a Professor of Pediatric Oncology in the Division of Child Health Obstetrics and Gynaecology, Medical School, University of Nottingham and Director of the Children’s Brain Tumour Drug Delivery Consortium. He is a world-renowned expert in the treatment of pediatric brain tumors and who shares the mission of this conference, making him an ideal candidate to deliver the key note address.
Live Webinar 1 Therapeutic Agent Delivery to the Brain: Clinical Perspectives Chair: Monica Pearl (Johns Hopkins University, Baltimore, MD, USA)
David Walker (University of Nottingham, UK)
In order to maintain a focused, intimate setting conducive to an open exchange of ideas and networking, the SIGN conference is organized to accommodate approximately 100 participants at the event. After feedback from colleagues in academia, small business and industry, we anticipate a broad global interest in our meeting and thus we plan to broadcast key components of the meeting. The webinar timing at 11:00 EST is to accommodate participants from both the US and Europe.
11:00 - 11:20 Invited: Graeme Woodworth, University of Maryland, Baltimore, MD, USA
Sound Power: Using Focused Ultrasound to Unlock Barriers to Drug Delivery in the Brain
11:20 - 11:40 Invited: Piotr Walczak, Johns Hopkins University, Baltimore, MD, USA
Imaging Tools to Improve Precision and Reproducibility of Intra-Arterial Drug Delivery
11:40 - 12:00 Invited: Steven Gill, North Bristol NHS Trust, UK
A System for Intermittent Convection Enhanced Drug Delivery to the Brain
12:00 - 13:00 Panel discussion with questions from the webinar
13:00 - 14:00 Lunch time
Lunch time presentation:
Invited: Codrin Lungu
Program Director, Division of Clinical Research,
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, USA
Funding Mechanisms for Training and Early Career
Invited: Chris H. Boshoff
Program Director, Division of Translational Research,
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, USA
Translational Research Funding for Biologics at NINDS
Mini Symposium 3 Intra-arterial approaches for treatment of stroke
Chair: Todd Abruzzo (Phoenix Children's Hospital, AZ, USA)
Anna Jablonska (Johns Hopkins University, Baltimore, MD, USA)
Endovascular mechanical thrombectomy has revolutionized the treatment of stroke over the last several years resulting in improved outcomes. This technology also opens up new opportunities for adjuvant treatment including stem cell-based therapies, local hypothermia and beyond. This session will focus on various approaches exploiting the intra-arterial route for the benefit of stroke patients.
14:00 - 14:15 Invited: Ming Ren, Xuanwu Hospital, Beijing, China
Selective Intraarterial Hypothermia Treatment for Acute Ischemia Stroke
14:15 - 14:30 Invited: Dileep Yavagal, University of Miami, FL, USA
Imaging to Determine Dosing in Intra-arterial Cell Delivery for Stroke
14:30 - 14:45 Invited: Michael E. Maniskas, University of Kentucky, Lexington, KY, USA
Instilling Healing: Intra-arterial Pharmacotherapy as an Adjunct to Thrombectomy in Ischemic Stroke
14:45 - 15:00 Invited: Shen Li, Dalian Hospital, Dalian, China
Acute Ischemic Stroke in Dalian, China
15:00 - 15:15 Invited: Paulo Henrique Rosado de Castro, Federal University of Rio de Janeiro, Brazil Imaging of Intravascular Cell Therapies for Stroke
15:15 - 15:30 Coffee break
Mini Symposium 4 Precise delivery to the brain through image-guidance
Chair: Ali Fatemi (Kennedy Krieger Institute, Baltimore, MD, USA)
Anna Andrzejewska (Mossakowski Medical Research Centre, PAS, Warsaw, Poland)
Direct targeting of therapeutics via the intra-arterial route is attractive for many neurological diseases. Neoplastic disease is a leading target; however, additional applications extend even beyond that and imaging plays a critical role in improving precision. These topics will be covered by the speakers of this symposium.
15:30 - 15:45 Invited: Dr. Monica Pearl, Johns Hopkins University, Baltimore, MD, USA
Intraarterial Chemotherapy For Brainstem Tumors
15:45 - 16:00 Invited: Dr. Michal Zawadzki, CCHMI, Warsaw, Poland
First-in-Human MRI-Guided Neuroendovascular Interventions
16:00 - 16:15 Invited: Ms. Elizabeth Vasconcellos, BrainLab, NY, USA
Multifaceted Approach to Optimizing Drug Delivery to the Brain
16:15 - 16:30 Coffee break
16:30 - 18:30 Early Stage Investigator Awards, rapid fire session and poster session.
See more information below
Early Stage Investigator Awards (ESIA) and Rapid Fire Session - Short Oral Presentation and Electronic Poster Session
Chair: Miroslaw Janowski (Johns Hopkins University, Baltimore, MD, USA)
Piotr Walczak (Johns Hopkins University, Baltimore, MD, USA)
Early Stage Investigator Award
First place Dominika Golubczyk, University of Warmia and Mazury, Olsztyn, Poland
Real-time MRI-guided endovascular model of cerebral ischemia in swine
Second place Shreyas Kuddannaya, Johns Hopkins University, Baltimore, MD, USA
Tracking Post-Transplantation Survival of Hydrogel-ScaffoldedGlial-Restriced Progenitors
Third place Raleigh Linville, Johns Hopkins University, Baltimore, MD, USA
Modeling Hyperosmotic and Peptide-Induced Blood-Brain Barrier Opening within Tissue- Engineered in vitro Human Brain Microvessels
Rapid Fire Session
Rohit K Srivastava, Johns Hopkins University, Baltimore, MD, USA
Biodistribution of Transplanted Glial Progenitors in 3D Printed Model of Brain Ventricular System
Kaja Kasarełło, Medical University of Warsaw, Poland
Antioxidant Mechanism of Action of Dimethyl Fumarate in Experimental AllergicEncephalomyelitis in Rats
Wei Zhu, Johns Hopkins University, Baltimore, MD, USA
Monitoring the Degradation of Implanted Hydrogels in the Brain using CEST MRI
Xiaoyan Lan, Johns Hopkins University, Baltimore, MD, USA
Feasibility Study of Ultra-High Dose Fractionated Radiation Therapy for Glioblastoma
Chengyan Chu, Johns Hopkins University, Baltimore, MD, USA
Optimization of Osmotic Blood-Brain Barrier Opening to Enable Intravital Microscopy Studies on Drug Delivery in a Mouse Cerebral Cortex
Anna Jablonska, Johns Hopkins University, Baltimore, MD, USA
Fluorine Nanoemulsion for Magnetic Resonance Imaging of Injectable Tissue Composites to Repair Intervertebral Discs
Joanna Kwiatkowska, University of Warmia and Mazury, Olsztyn, Poland
Histological Assessment of Neuroinflammation after Ischemic Brain Injury in Swine EndovascularStroke Model
Lukasz Kalkowski, University of Warmia and Mazury, Olsztyn, Poland
Intraarterial Cell Delivery with MRI Guidance as a Platform for Stem Cell Therapy in Large Animal Model
Bela Turk, Kennedy Krieger Institute, Baltimore, MD, USA
Magnetization Transfer Imaging in the Adrenomyeloneuropathy Spinal Cord Shows Longitudinal Suitability as a Potential Biomarker for Clinical Trial
Mitsuyoshi Watanabe, University of Miami, FL, USA
Maximum Tolerated Dose of Exosomes Derived from Mesenchymal Stem Cells via Intra-arterial Dosing in a Rat Stroke Model
Anna Andrzejewska, Mossakowski Medical Research Centre, PAS, Warsaw, Poland
Superparamagnetic Iron Oxide Nanoparticles as Optimal Label for Genetically Engineered Mesenchymal Stem Cell in Term of Their Visualisation and Homing Assessment After Transplantation
Sylwia Dabrowska, Mossakowski Medical Research Centre, PAS, Warsaw, Poland
Imaging of Extracellular Vesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Using Fluorescent and Magnetic Labels; in vitro and in vivo Studies
Luiza Stanaszek, Mossakowski Medical Research Centre, PAS, Warsaw, Poland
Gellan Gum (GG) Based Hydrogels as Potential Scaffolds for Intrathecal Stem Cell Delivery in Demyelination Models of Mice
Piotr Rogujski, Mossakowski Medical Research Centre, PAS, Warsaw, Poland
Alginate-Based hydrogels Used as Potential Scaffolds for Mesenchymal Stem Cells Delivery inShiverer Mice Therapy
Larissa Jank, University of Hamburg-Eppendorf, Germany
Intraarterial P2X7 Nanobodies in Stroke
18:30 - 19:00 SIGN business meeting
19:30 - 23:00 Networking event
Sotto Sopra
DAY 2. June 11, 2019 Baltimore, MD
7:30 - 8:15 Registration and continental breakfast
Mini Symposium 5 Advances in neuroimaging
Chair: Peter van Zijl (Kennedy Krieger Institute, Baltimore, MD, USA)
Bela Turk (Kennedy Krieger Institute, Baltimore, MD, USA)
Different modalities applicable to neuroimaging will be a central element of this mini symposium. This will include magnetic resonance imaging, magnetic particle imaging, PET and optical imaging. Particular emphasis will be made on modalities and techniques that aid in improving precision of drug delivery to the brain.
8:00 - 8:15 Invited: Peter Ludewig, University of Hamburg-Eppendorff, Germany
Magnetic Particle Imaging for Neurological Applications
8:15 - 8:30 Invited: Michael McMahon, Kennedy Krieger Institute, Baltimore, MD, USA
Organic Theranostic Agents for Interventional MRI,
8:30 - 8:45 Invited: Marcel Daadi, Texas Biomedical Research Institute, San Antonio, TX, USA
Interventional Magnetic Resonance Imaging-Guided Transplantation of Neural Stem Cell Progeny Into the Brain
8:45 - 9:00 Invited: Wojciech Lesniak, Johns Hopkins University, Baltimore, MD, USA
Radiolabeling of Therapeutic Agents and PET Imaging for Precision Medicine,
9:15 - 9:30 Invited: Qin Qin, Johns Hopkins University, Baltimore, MD, USA
Novel Techniques for Non-Contrast Cerebral MR Angiography
Mini Symposium 6 Preclinical research on animal models
Chair: Jeff Bulte (Johns Hopkins University, Baltimore, MD, USA)
Larissa Jank (University of Hamburg-Eppendorf, Germany)
Animal models of neurological disease with improved clinical relevance.
Rodent disease models to date dominate preclinical research, however, considering the size of the human brain, these models lack clinical relevance. We will discuss the need and opportunities for introducing large animal models including swine and dogs or companion animals with naturally occurring neurological diseases.
9:30 - 9:45 Invited: Johannes Boltze, University of Warwick, UK
Stroke Modelling and Neuroimaging in Sheep
9:45 - 10:00 Invited: Rebecca Krimins, Johns Hopkins University, Baltimore, MD, USA
Learning from Brain Cancer in Pets
10:00 - 10:15 Invited: Yajie (Kevin) Liang, Janelia Research Campus, HHMI, Ashburn, VA, USA
Intravital Two-Photon Microscopy: State-of-The-Art And Prospects for Clinical Applications
10:15 - 10:30 Coffee break and discussion
10:30 - 11:00 Keynote address: Prof. Sean Savitz (University of Texas, Houston, TX, USA)
NeuroImaging: Transforming Personalized Medicine for Neurological Disorders
Sean Savitz is a Professor of Neurology and Director of Stroke Institute at University of Texas. He is a world-renowned expert in the treatment of neurological disorders. He focuses on stroke, a medical field which has greatly benefitted recently from advanced imaging to optimally select patients for neurointerventions; therefore, he is well suited to provide a perspective on clinical needs to further advance image guided neurointerventions.
Live Webinar 2 Technological Advances
Chair: Miroslaw Janowski (JHU, Baltimore, MD, USA)
Jaroslaw Maciaczyk (University of Otago, Dunedin, New Zealand)
This second webinar will continue on the topic of new technologies that are critical for successful drug delivery to the brain.
11:00 - 11:20 Invited: Edward A. Neuwelt, Oregon Health and Science University, Portland, USA
The Blood-Brain Barrier in Brain Tumor Therapy: Intra-Arterial Chemotherapy
11:20 - 11:40 Invited: Henry Brem, Johns Hopkins University, Baltimore, MD, USA
Novel Approaches to Therapeutic Brain Delivery
11:40 - 12:00 Invited: Mark Souweidane, Weill Cornell, New York, NY, USA
Strategies to Overcome Barriers of Convection Enhanced Delivery (CED) for CNS Tumors
12:00 - 13:00 Panel discussion
13:00 - 14:00 Lunch time
Mini Symposium 7 Biomaterials and Nanotechnologies
Chair: Jordan J. Green (Johns Hopkins University, Baltimore, MD, USA)
Xiaoyan Lan (Johns Hopkins University, Baltimore, MD, USA)
Advances in material sciences offer practically unlimited access to biomaterials with customized biomechanical properties and biological activity. These biomaterials can be used for slow release of drugs, structural support or a favorable milieu for transplanted stem cells.
14:00 - 14:15 Invited: Marcin Kortylewski, Beckman Research Institute at City of Hope, Duarte, CA, USA
Optimizing TLR9-Targeted STAT3 Inhibitors for Glioma Immunotherapy
14:15 - 14:30 Invited: Michel Modo, University of Pittsburgh, PA, USA
Magnetic Resonance Imaging-Based Guidance and Monitoring of Biomaterial Implantation Into the Stroke-Damaged Brain
14:30 - 14:45 Invited: Ruman Rahman, University of Nottingham, UK
A Neurosurgically-Applied Thermo-Sensitive Paste For the Delivery of
Brain Tumour Chemo- and Nano-Therapies
14:45 - 15:00 Invited: Jaroslaw Maciaczyk, Univerity of Otago, Dunedin, New Zealand
Clipping the Wings - Cancer Stem Cells and Challenges of Image-Guided Therapy of Glioblastoma
15:00 - 15:15 Invited: Khuloud Al-Jamal, King's College, London
Overcoming the Blood Brain Barrier using Nanomedicines
15:15 - 15:30 Invited: Webster Kadzatsa, University of Zimbabwe, Harrare, Zimbabwe
From Roentgen and Sklodowska-Curie to Cure of Brain Tumors, the Sign of Progress Now Showing
15:30 - 15:45 Coffee break
Mini Symposium 8 Focused ultrasound
Chair: Peter Searson (Johns Hopkins University, Baltimore, MD, USA)
Wei Zhu (Johns Hopkins University, Baltimore, MD, USA)
Focused ultrasound is a technology that is making significant strides towards clinical applications. After spectacular success with treatment of essential tremor, it is now entering the clinical realm for spatially precise opening of the blood brain barrier to improve delivery of therapeutic agents. It also facilitates removal of potentially toxic agents such as amyloid, opening a new perspective for the treatment of Alzheimer’s disease.
15:45 - 16:00 Invited: Victor Frenkel, University of Maryland, Baltimore, MD, USA
The Paradox of Ultrasound Effects on The Extracellular Space: How Expanding These Regions Can Enhance Both Local and Systemic Delivery
16:00 - 16:15 Invited: Hong Chen, Washington University, St. Louis, MO, USA
Image-Guided Focused Ultrasound-Mediated Brain Drug Delivery
16:15 - 16:30 Invited: Raag Airan, Stanford University, CA, USA
Targeted Drug Delivery to the Nervous System with Ultrasonic Drug Uncaging
16:30 - 16:45 Invited: Costas Arvanitis,Georgia Institute of Technology, Atlanta, GA, USA
Controlled Drug Delivery and Release to Brain Tumors with Focused Ultrasound
16:45 - 17:00 Invited: Rao Gulapalli, University of Maryland, Baltimore, MD, USA
Exploring Strategies to Improve Workflow Associated with MRgFUS
Closing Ceremony and Awards
17:00 - 17:15 President of SIGN - Miroslaw Janowski, Johns Hopkins University, Baltimore, MD, USA
Chairman of CBTDDC - David Walker, University of Nottingham, UK